Trka Receptor Signaling Pathway
| PAG Title | Trka Receptor Signaling Pathway |
| PAG ID | WIG000454 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine kinase receptors that also includes TrkB and TrkC. Some NGF responses are also mediated or modified by p75LNTR, a low affinity neurotrophin receptor. Binding of NGF to TrkA stimulates neuronal survival, and also proliferation. Pathways coupled to these responses are linked to TrkA through association of signaling factors with specific amino acids in the TrkA cytoplasmic domain. Cell survival through inhibition of apoptosis is signaled through activation of PI3-kinase and AKT. Ras-mediated signaling and phospholipase C both activate the MAP kinase pathway to stimulate proliferation. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 3,339 |
| Information Content | Rich |
| Other IDs | M9134 |
| Base PAG ID | WIG000454 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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